Manuscript, Study supervision, authorized final version on the manuscript. VW: Important revision of manuscript, Study supervision, authorized final version of the manuscript. Ethics approval and consent to participate This study was approved by the QIMR Berghofer Human Research Ethics Committee. All participants gave informed, written consent prior to participation in this study. Consent for publication Not applicable. Competing interests The authors declare they’ve no competing interests.University of your Sunshine Coast, Sunshine Coast, QLD, Australia. 3School of Medicine, University of Queensland, Brisbane, QLD, Australia. 4Envoi Specialist Pathology, Brisbane, QLD, Australia. 5Queensland University of Technologies, Faculty of Well being, Brisbane, QLD, Australia. 6Department of Gastroenterology and Hepatology, RBWH, Brisbane, QLD, Australia. 7Pathology Queensland, Brisbane, QLD, Australia. Received: 17 October 2017 Accepted: 20 DecemberPublisher’s NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Author specifics 1 Conjoint Gastroenterology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.m-PEG12-acid Formula 2School of Health and Sport Science,References 1. Bettington M, Walker N, Clouston A, Brown I, Leggett B, Whitehall V. The serrated pathway to colorectal carcinoma: present concepts and challenges.2-Hydroxy-1-morpholin-4-ylethanone site Histopathology. 2013;62(3):3676. 2. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61(5):7597. three. Pino MS, Chung DC. The chromosomal instability pathway in colon cancer. Gastroenterology. 2010;138(six):20592. 4. Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, et al. Mutations in the BRAF gene in human cancer. Nature. 2002;417(6892):9494. 5. Spring KJ, Zhao ZZ, Karamatic R, Walsh MD, Whitehall VLJ, Pike T, Simms LA, Young J, James M, Montgomery GW, et al. Higher prevalence of sessile serrated adenomas with BRAF mutations: a potential study of patients undergoing colonoscopy. Gastroenterology. 2006;131(5):1400. 6. Weisenberger DJ, Siegmund KD, Campan M, Young J, Lengthy TI, Faasse MA, Kang GH, Widschwendter M, Weener D, Buchanan D, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly connected with BRAF mutation in colorectal cancer. Nat Genet. 2006; 38(7):7873. 7. Toyota M, Ahuja N, Ohe-Toyota M, Herman JG, Baylin SB, Issa J-PJ. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A. 1999;96(15):8681. 8. Deng G, Chen A, Hong J, Chae HS, Kim YS. Methylation of CpG within a smaller region of your hMLH1 promoter invariably correlates with the absence of gene expression.PMID:35567400 Cancer Res. 1999;59(9):2029. 9. Sepp TT, B m JP, Friman M, Lahtinen L, V rynen VMJ, Liipo TKE, Ristim i AP, Kairaluoma MVJ, Kellokumpu IH, Kuopio THI, et al. Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer. Br J Cancer. 2015;112(12):19665. 10. Bettington M, Walker N, Rosty C, Brown I, Clouston A, McKeone D, Pearson SA, Leggett B, Whitehall V. Clinicopathological and molecular attributes of sessile serrated adenomas with dysplasia or carcinoma. Gut. 2017;66(1):9706. 11. Bettington ML, Walker NI, Rosty C, Brown IS, Clouston AD, McKeone DM, Pearson S-A, Klein K, Leggett BA, Whitehall VLJ. A clinicopathological and molecular evaluation of 200 conventional serrated adenomas. Mod Pathol. 2015; 28(3):4147. 12.