Product Name :
NME1 Mouse Monoclonal Antibody [C6-B2]
Predicted band size :
Observed band size :
Synonyms:
AWD antibody AWD drosophila homolog of antibody GAAD antibody Granzyme A activated DNase antibody Granzyme A-activated DNase antibody GZMA activated DNase antibody Metastasis inhibition factor NM23 antibody NB antibody 展开
Function :
The nm23 protein is implicated in a variety of biological processes, including suppressing metastasis, phytochrome responses in plants and regulating differentiation. Nm23-H1, nm23-H2 and nm23-H2, members of the nm23 family, are putative metastasis suppressor genes that encode nucleoside diphosphate kinase (NDPK) A and B. NDPKs form oligomers, which are distributed in both the soluble and particulate fractions of cells. Upon cAMP-induced differentiation of rat cells, nm23 proteins show a differential interaction with intermediate filaments. Both isoforms also associate with GFAP in differentiated cells. nm23 proteins and their mutants are localized predominantly in the mitochondria. Nm23 mutants are unable to inhibit differentiation and promote apoptosis as a results of defective protein-protein interactions in the mitochondria. Nm23-H1, nm23-H2 and nm23-H3 are indicators of a poor prognosis in human hematopoietic malignancies, and as a high expression of nm23-H1 and -H2 is positively correlated with histological
Antibody Type:
Mouse Monoclonal Antibody
Immunogen :
Recombinant protein
Species reactivity:
Human
Verify application:
WB, ICC, IHC-P, FC
Coupling :
unconjugated
Clone number:
C6-B2
RRID:
Form :
Liquid
Concentration :
2ug/ul
Storage instructions:
4℃; -20℃ for long term storage.Formula of 2,4-Dichloro-5,6-dimethylpyrimidine
Storage buffer solution:
Purified antibody in PBS with 0.6-Bromochroman-4-amine Chemscene 05% sodium azide.PMID:33738685
Subtype:
IgG1
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
17 kDa
Positive control :
NME1-hIgGFc transfected HEK293 cell lysate, human placenta tissue, Hela, Jurkat.