Product Name :
NK-p44 Recombinant Rabbit Monoclonal Antibody [JE61-04]
Predicted band size :
Observed band size :
Synonyms:
Activating NK receptor NKp44 antibody CD336 antibody CD336 antigen antibody dJ149M18.1 antibody LY95 antibody Lymphocyte antigen 95 (activating NK receptor NK p44) antibody Lymphocyte antigen 95 homolog (activating NK receptor NK p44) antibody Lymphocyte antigen 95 homolog antibody 展开
Function :
Natural killer (NK) cells direct cytotoxicity against tumor or virally infected cells. NK cell-mediated cytotoxicity is stimulated by several activating receptors associated with the signaling adapter DNAX activation 12/killer cell-activating receptor-associated protein (DAP12). NKp44 is a natural cytotoxicity receptor that is is expressed on IL-2-activated human NK cells and may contribute to the increased efficiency of NK cells to mediate tumor cell lysis. NKp44 is composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. Prolactin up-regulates and cortisol down-regulates the surface expression of NKp44 at the transcriptional level. A cellular ligand for NKp44 (NKp44L) is expressed during HIV-1 infection and is correlated with the progression of CD4+ T cell depletion and an increase of viral load. This implicates NKp44 as a therapeutic agent that may aid in the progress towards a vaccine for HIV-1 infection.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within human NK-p44 aa 1-100/276.83624-01-5 Chemical name
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
JE61-04
RRID:
AB_3072009
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.2-Oxa-6-azaspiro[3.3]heptane Chemscene Aliquot store at -20℃.PMID:33522329 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
31 kDa
Positive control :
K562 cell lysate, HL-60 cell lysate, human small intestine tissue, mouse kidney tissue.