Chopp M: Intravenous administration of human umbilical cord blood reduces behavioral deficits immediately after stroke in rats. Stroke 2001, 32(11):2682?688. 28. Xiong LZ, Yang J, Wang Q, Lu ZH: Involvement of delta-and mu-opioid receptors inside the delayed cerebral ischemic tolerance induced by repeated electroacupuncture preconditioning in rats. Chin Med J 2007, 120(5):394?99. 29. Zhu JM, Zhao YY, Chen SD, Zhang WH, Lou L, Jin X: Functional recovery soon after transplantation of neural stem cells modified by brain-derived neurotrophic factor in rats with cerebral ischaemia. J Int Med Res 2011, 39(2):488?98. 30. Cui X, Chopp M, Zacharek A, Roberts C, Buller B, Ion M, Chen J: Niacin therapy of stroke increases synaptic plasticity and axon development in rats. Stroke 2010, 41(9):2044?049. 31. Ke Z, Yip SP, Li L, Zheng XX, Tong KY: The effects of voluntary, involuntary, and forced workout routines on brain-derived neurotrophic aspect and motor function recovery: a rat brain ischemia model.156939-62-7 web PLoS One 2011, six(two):e16643. 32. Schabitz WR, Schwab S, Spranger M, Hacke W: Intraventricular brain-derived neurotrophic issue reduces infarct size immediately after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1997, 17(five):500?06. 33. Snider BJ, Du C, Wei L, Choi DW: Cycloheximide reduces infarct volume when administered up to six h immediately after mild focal ischemia in rats. Brain Res 2001, 917(two):147?57. 34. Katchanov J, Harms C, Gertz K, Hauck L, Waeber C, Hirt L, Priller J, von Harsdorf R, Bruck W, Hortnagl H, Dirnagl U, Bhide PG, Endres M: Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery ahead of delayed neuronal cell death.926659-01-0 manufacturer J Neurosci 2001, 21(14):5045?053. 35. Cheng CY, Su SY, Tang NY, Ho TY, Chiang SY, Hsieh CL: Ferulic acid delivers neuroprotection against oxidative stress-related apoptosis just after cerebral ischemia/reperfusion injury by inhibiting ICAM-1 mRNA expression in rats. Brain Res 2008, 1209:136?50. 36. Nakazawa T, Tamai M, Mori N: Brain-derived neurotrophic element prevents axotomized retinal ganglion cell death by way of MAPK and PI3K signaling pathways. IOVS 2002, 43(10):3319?326. 37. Wang X: The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci Ther 2009, 15(4):345?57. 38. Koh PO: Estradiol prevents the injury-induced decrease of 90 ribosomal S6 kinase (p90RSK) and Negative phosphorylation. Neurosci Lett 2007, 412(1):68?2. 39. Zhu Y, Yang GY, Ahlemeyer B, Pang L, Che XM, Culmsee C, Klumpp S, Krieglstein J: Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against harm.PMID:28322188 J Neurosci 2002, 22(10):3898?909. 40. Tanaka Y, Tanaka R, Liu M, Hattori N, Urabe T: Cilostazol attenuates ischemic brain injury and enhances neurogenesis in the subventricular zone of adult mice after transient focal cerebral ischemia. Neuroscience 2010, 171(four):1367?376.doi:10.1186/1472-6882-14-92 Cite this article as: Cheng et al.: Electroacupuncture-like stimulation at Baihui and Dazhui acupoints exerts neuroprotective effects by means of activation from the brain-derived neurotrophic factor-mediated MEK1/2/ ERK1/2/p90RSK/bad signaling pathway in mild transient focal cerebral ischemia in rats. BMC Complementary and Option Medicine 2014 14:92.
The complex regulation of metabolic activity within cancer cells is important to their survival and proliferation. AMP-activated protein kinase (AMPK) plays a central role in preserving power homeostasis as a sensor of cellular energy levels in bot.