Per protocol set)Week 26 28 30 32 34 36 38 40 42 44 Plasma folate Levomefolate calcium 0 (0.0) 4 (5.3) 5 (6.7) 11 (14.7) 15 (20.0) 23 (30.7) 25 (33.3) 30 (40.0) 30 (40.0) 44 (58.7) Folic acid 0 (0.0) four (5.three) eight (10.7) 12 (16.0) 17 (22.7) 23 (30.7) 25 (33.3) 34 (45.3) 38 (50.7) 45 (60.0) RBC

Per protocol set)Week 26 28 30 32 34 36 38 40 42 44 Plasma folate Levomefolate calcium 0 (0.0) 4 (five.3) five (6.7) 11 (14.7) 15 (20.0) 23 (30.7) 25 (33.3) 30 (40.0) 30 (40.0) 44 (58.7) Folic acid 0 (0.0) four (5.3) eight (10.7) 12 (16.0) 17 (22.7) 23 (30.7) 25 (33.3) 34 (45.3) 38 (50.7) 45 (60.0) RBC folate Levomefolate calcium 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 1 (1.three) 2 (2.7) two (2.7) six (8.0) 7 (9.3) eight (ten.7) Folic acid 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 0 (0.0) 2 (2.7) 2 (two.7) 2 (two.7) 3 (4.0) six (eight.0) Homocysteine Levomefolate calcium four (five.three) 8 (ten.7) 11 (14.7) 14 (18.7) 16 (21.3) 19 (25.3) 20 (26.7) 22 (29.3) 25 (33.3) 26 (34.7) Folic acid 2 (two.7) 5 (6.7) 9 (12.0) 12 (16.0) 14 (18.7) 17 (22.7) 23 (30.7) 26 (34.7) 29 (38.7) 30 (40.0)Notes: Data are n ( ). The imply median baseline values were as follows for EE-drospirenone-levomefolate calcium and EE-drospirenone + folic acid, respectively: plasma folate, 16.2-Bromo-5-fluoro-4-nitropyridine web four and 14.Formula of 30094-32-7 1 nmol/L; RBC folate, 578.3 and 550.2 nmol/L; homocysteine, 9.three and 9.two ol/L. Abbreviations: EE, ethinylestradiol; RBC, red blood cells.International Journal of Women’s Health 2013:submit your manuscript | dovepressDovepressDiefenbach et al1.DovepressSurvival distribution function0.0.0.0.0.0 24 26 28 30 32 34 36 38 40 42Time (study week) to falling of RBC folate below 906 nmol/LFigure five Kaplan eier estimates for time to RBC folate levels falling below 906 nmol/L for EE-drospirenone following treatment with EE-drospirenone-levomefolate calcium (per protocol set). Abbreviations: EE, ethinylestradiol; RBC, red blood cell.reduced degree of quantification were noted in plasma in some women (Table 4). Comparison of remedy groups didn’t reveal variations with regard to either the metabolite concentrations above the reduced degree of quantification or100 90 80 70the percentage of girls with metabolite concentrations below the reduced degree of quantification (Figure 7) following day-to-day intake of equimolar doses of levomefolate calcium or folic acid.L-MTHF50 40 30 20 10-10 MTHF, visitFA, visitMTHF, visitFA, visitMTHF, visitFA, visitFigure six Distribution of person L-MTHF plasma concentrations [nmol/L] at baseline (stop by 1), week 12 (check out 8), and week 24 (pay a visit to 14) after daily oral administration of EE-drospirenone-levomefolate calcium (MTHF) or EE-drospirenone + FA.PMID:23439434 Note: Reduce degree of quantification for L-MTHF was among 3.325 and three.680 nmol/L. Abbreviations: EE, ethinylestradiol; FA, folic acid; L-MTHF, L-5-methyl-tetrahydrofolate.submit your manuscript | dovepressInternational Journal of Women’s Wellness 2013:DovepressDovepressEE-drospirenone-levomefolate calcium versus EE-drospirenone + folic acidTable 4 Mean metabolite concentrations in plasma (nmol/L)EE-drsp-levomefolate calcium THF Baseline Week 12 Week 24 four.07 ?0.357 (n = 4) four.98 ?1.851 (n = 13) 5.92 ?two.318 (n = 23) 5,10-methenyl-THF 1.57 ?0.412 (n = 9) 1.76 ?0.603 (n = 7) 1.46 ?0.238 (n = 12) EE-drsp + folic acid THF 4.60 ?0.656 (n = 7) five.28 ?1.806 (n = 14) 5.76 ?2.835 (n = 19) five,10-methenyl-THF 1.63 ?0.372 (n = 8) 1.45 ?0.282 (n = 7) 1.95 ?1.166 (n = 12)Notes: Values are presented because the mean ?normal deviation. Reduce level of quantification = THF, between three.447 and 3.539 nmol/L; five,10-methenyl-THF, among 1.052 and 1.284 nmol/L. Abbreviations: drsp, drospirenone; EE, ethinylestradiol; THF, tetrahydrofolate.PregnanciesTwo pregnancies occurred during the study. One volunteer became pregnant before the start off of therapy (ie, through the screening period). This volunteer was not integrated in.