, ChiMei Health-related Center, Tainan; 4Department of Pathology, Taipei Health-related University, Taipei, TaiwanReceived: December 14, 2012 Revised: February 6, 2013 Accepted: February 28, 2013 Corresponding Author ShihSung Chuang, M.D. Department of Pathology, ChiMei Health-related Center, 901 ChungHwa Road, YungKang District, Tainan 710, Taiwan Tel: 88662812811 (ext. 53686) Fax: 88662511235 E-mail: [email protected] dendritic cell (FDC) sarcoma is uncommon and is classified either as traditional kind or inflammatory pseudotumor (IPT)like variant. Extranodal presentation is uncommon and practically all gastrointestinal FDC tumors are of the standard type. IPTlike variant tumors occur pretty much exclusively inside the liver and spleen and are regularly associated with EpsteinBarr virus (EBV). Right here we report the case of a 78yearold lady with an IPTlike FDC sarcoma presenting as a pedunculated colonic polyp. Histologically, scanty atypical ovoid to spindle cells have been mixed with a background of florid lymphoplasmacytic infiltrate, which led to an initial misdiagnosis of pseudolymphoma. These atypical cells expressed CD21, CD23, CD35, and D240, and had been positive for EBV by in situ hybridization, confirming the diagnosis. The patient was absolutely free of disease five months just after polypectomy with no adjuvant therapy. Although very uncommon, the differential diagnosis for colonic polyp really should include things like FDC sarcoma to prevent an erroneous diagnosis. A evaluation of the 24 circumstances of IPTlike FDC sarcoma reported inside the literature reveal that this tumor happens predominantly in females using a predilection for liver and spleen, and features a strong association with EBV.Important Words: Colon polyp; EpsteinBarr virus; Follicular dendritic cell sarcoma; Inflammatory pseudotumor; TaiwanFollicular dendritic cells (FDC) are antigenpresenting cells normally residing within the germinal centers of secondary lymphoid follicles. Initial described in 1986 by Monda et al.,1 FDC sarcoma is usually a rare neoplasm comprising spindled to ovoid cells showing morphological and immunophenotypic functions of FDC admixed with scattered modest lymphocytes, i.e., the classical or conventional histopathology.1,two In the inflammatory pseudotumor (IPT)like variant, which occurs exclusively inside the liver or spleen, the neoplastic spindle cells are scarce and are dispersed inside a prominent lymphoplasmacytic infiltrate.two,three One particular half to two thirds of FDC sarcomas are nodal lesions, most commonly in the cervical and axillary nodes; extranodal FDC sarcoma is rare with only about one hundred circumstances being reported.four,5 Extranodal tumors preferentially have an effect on the pelvic, abdominal and head and neck regions, with a minority involving the gastrointestinal (GI) tract.five,6 Morphologically, all the hepatic lesions which have been described have belonged to the IPTlike variant, even though the majority of the extrahepatic lesions like GI tumors have been in the conventional variety.1158264-69-7 Formula 5,six Cheuk et al.1629051-80-4 Chemscene three reported the biggest series of IPTlike FDC sarcoma, with all 11 instances occurring within the abdominal cavity and with overrepresentation of female sufferers and hepatosplenic involvement.PMID:24624203 3 Moreover, all tumors in the series had been positive for EpsteinBarr virus (EBV) by in situ hybridization. Right here we report an EBVpositive, IPTlike variant of FDC sarcoma presenting as a colonic polyp, a peculiar presentation which has in no way been reported previously.CASE REPORTA 78yearold female presented with a number of months of abdominal discomfort and bloody stool. The patient also reported.